Lipoedema & Mast Cell Activation Syndrome (MCAS)

illustration of three mast cells showing mediator release and their effects on fluid movement, inflammation and nerve sensitivity

Introduction Mast cells are part of normal human physiology and are best known for their role in allergic reactions. They sit within connective and adipose tissues, particularly around blood vessels, lymphatic vessels and peripheral nerves, as well as in areas such as the skin, respiratory mucosa and gastrointestinal lining where potential toxins, irritants or antigens […]